Document Type : Research Paper
Authors
1 Department of Biology, College of Sciences, University of Anbar , Iraq
2 Department of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University
Abstract
Introduction and aim: Psoriasis is a skin condition that causes flaky patches of skin which form scales normally appear on elbows, knees, scalp and lower back, but can appear anywhere on body. The study aims to evaluate the correlation between lipid profile variables with the development of psoriasis within group subjects. Materials and Methods: The study included 310 subjects, males and females aged (25-65) years. The patients were attending a dermatology consultant at Al-Yarmouk Teaching Hospital in Baghdad. Blood samples were collected by venipuncture from all individuals. Biolis 24i automated analyzer was used to estimate serum levels of Cholesterol, Triglyceride, HDL, LDL, and VLDL. Results: The incidence, prevalence, and manifestation of psoriasis of the skin are similar between different sexes in psoriasis, there is overexpression of lipid profile related tests, as these variables could impact each other. High levels of Cholesterol, Triglyceride, HDL, LDL, and VLDL in psoriatic patients were recorded comparing with healthy controls. However, it was found that considerable effect of the progression of psoriasis on the elevated levels of lipid profile in such individuals. Conclusion: The incidence and prevalence of the disease varies in both sexes. However, all physiological levels of understudy variables were increased in patients with psoriasis, and this may play a major role in the development of the disease.
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Main Subjects
- Parisi, R.; Iskandar, I.Y.K.; Kontopantelis, E.; Augustin, M.; Griffiths, C.E.M.; Ashcroft, D.M. (2020). National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study. BMJ. 369:m1590. doi: 10.1136/bmj.m1590.
- Ramessur, R.; Corbett, M.; Marshall, D.; Acencio, M.L.; Barbosa, I.A.; Dand, N.; Di Meglio, P.; Haddad, S.; Jensen, A.H.M.; Koopmann, W.; Mahil, S.K.; Ostaszewski, M.; Rahmatulla, S.; Rastrick, J.; Saklatvala, J.; Weidinger, S.; Wright, K.; Eyerich, K.; Ndlovu, M.; Barker, J.N.; Skov, L.; Conrad, C.; Smith, C.H. (2022). Biomarkers of disease progression in people with psoriasis: a scoping review. British Journal of Dermatology. 187(4): 481-493. doi.org/ 10.1111/ bjd.21627.
- Ford, A.R.; Siegel, M.; Bagel, J.; Cordoro, K.M.; Garg, A.; Gottlieb, A. (2018). Dietary Recommendations for Adults with Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation: A Systematic Review. JAMA Dermatol [Internet]. 154(8):934-950.
- Papp, K.A.; Lebwohl, M.G.; Kircik, L.; Pariser, D.; Strober, B.; Krueger, G.; Higham, R.C. (2021). The PASI-HD improved precision in measuring disease severity in subjects with mild to moderate plaque psoriasis treated with roflumilast cream, a phosphodiesterase-4 inhibitor. Journal of the American Academy of Dermatology. 85(3): AB164.
- Capon, F. (2017). The genetic basis of psoriasis. International journal of molecular sciences. 18(12): 25-26.
- Elnabawi, Y.A.; Dey, A.K.; Goyal, A.; Groenendyk, J.W.; Chung, J.H.; Belur, A.D.; Mehta, N. N. (2019). Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study. Cardiovascular research. 115(4): 721-728.
- Sirin, M.C.; Korkmaz, S.; Erturan, I.; Filiz, B.; Aridogan, B.C.; Cetin, E.S.; Yildirim, M. (2020). Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with Psoriasis. Anais brasileiros de dermatologia. 95: 575-582. doi.org/ 10.53350 /pjmhs22164940.
- Mora, S. (2016). Nonfasting for routine lipid testing: From evidence to action. JAMA Intern Med. 176 (7): 1005–1006.
- Anderson, L.N.; Maguire, J.L.; Lebovic, G.; Hanley, A.J.; Hamilton, J.; Adeli, K. (2017). Duration of fasting, serum lipids, and metabolic profile in early childhood. The Journal of Pediatrics. 180: 47–52.
- Raj, D.M.; Ravi, K.; Sankar, S. A. (2017). study on preanalytical errors in EDTA blood collected for cell counting. J Evol Med Dent Sci. 6(22): 1788-1794.
- Sundstrom, K.; Lamin, H.; Dillner, J. (2021). Validation of the cobas 6800 (e411) human papillomavirus test in primary cervical screening. PLoS One. 16(2): e247291. doi: 10.1371/journal.pone.0247291.
- Brazzelli, V.; Maffioli, P.; Bolcato, V.; Ciolfi, C.; D'Angelo, A.; Tinelli, C.; Derosa, G. (2021). Psoriasis and diabetes, a dangerous association: evaluation of insulin resistance, lipid abnormalities, and cardiovascular risk biomarkers. Frontiers in Medicine. 8: 605-610.
- Lea, W.A.; Cornish, H.H.; Block W.D. (1958). Studies on serum lipids, proteins, and lipoproteins in psoriasis. J Invest Dermatol. 30(4):181–185.
- Coban, M.; Tasli, L.; Turgut, S.; Özkan, S.; Ata, M.T.; Akin, F. (2016). Association of adipokines, insulin resistance, hypertension and dyslipidemia in patients with psoriasis vulgaris. Annals of dermatology. 28(1): 74-79. doi.org/10.5021/ad. 2016. 28. 1.74.
- Corbetta, S.; Angioni, R.; Cattaneo, A.; Beck-Peccoz, P.; Spada, A. (2006). Effects of retinoid therapy on insulin sensitivity, lipid profile and circulating adipocytokines. Eur J Endocrinol. 154(1):83-86. doi: 10.1530/eje.1.02057.PMID: 16381995.
- Nowowiejska, J.; Baran, A.; Flisiak, I. (2023). Lipid Alterations and Metabolism Disturbances in Selected Inflammatory Skin Diseases. Int J Mol Sci. 24(8):7053. doi: 10.3390/ijms24087053.
- Pietrzak, A.; Lecewicz-Toruń, B.; Kadziela-Wypyska, G. (1998). Changes in the digestive system in patients suffering from psoriasis. Ann Univ Mariae Curie Sklodowska Med. 53:187–194.
- Sachdev, S.S.; Jamil, A.; Gunabalasingam, P.; Safdar, N.A. (2022). The Effects of Acitretin on Insulin Resistance, Glucose Metabolism, and Lipid Levels in Patients with Psoriasis. Indian J Dermatol. 67(4): 349-354. doi: 10.4103/ijd.ijd-328-21.
- Castro, K.R.; Aikawa, N.E.; Saad, C.G. (2011). Infliximab induces increase in triglyceride levels in psoriatic arthritis patients. Clin Dev Immunol. 2011:352686.
- Mallbris, L.; Granath, F.; Hamsten, A.; Stahle, M. (2006). Psoriasis is associated with lipid abnormalities at the onset of skin disease. J Am Acad Dermatol. 54(4):614–621.
- Piskin, S.; Gurkok, F.; Ekuklu, G.; Senol, M. (2003). Serum lipid levels in psoriasis. Yonsei Med J. 44(1):24–26.
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