Preparation, Antimicrobial Evaluation and Molecular docking of New 2,3-Substituted [1,3] Benzooxazin-4-one derivatives

Al-Naseeri, Ali; Saleh, Hanaa K.; Jassim, Ibtisam K.

doi:10.37652/juaps.2022.172385

Document Type : Research Paper

Authors

¹ Department of Chemistry, College of Science, University of Anbar, Anbar, Iraq

² Department of Chemistry, College of Science, Tikrit University, Tikrit, Iraq

³ Department of Chemistry, College Ibn-Al-Haitham, Baghdad, Iraq

https://doi.org/10.37652/juaps.2022.172385

Abstract

New 2, 3-substituted benzooxazin-4-one derivatives were prepared by means of a altered step by step proceedings in which Schiff bases were substituted with salicylic acid for a ring forming reaction. The compositions of the synthesized compounds were certain via methods spectrometry as elemental analysis, FT-IR, 13C-NMR & 1H-NMR spectral analysis. The bio-activities for the prepared compounds in-vitro as antibacterial and antifungal were estimated as opposed to two races of gram-positive & two races of gram-negative bacteria as parallel to Cefotaxime sodium as regular drug and assessed versus two types of fungi. The prepared compounds were got to have antimicrobial activities spreading from middling to perfect against of the bacteria strains with good percentage mycelial growth inhibition activity against fungi. Molecular docking displays the critical part while effect of variety of substituents on biological activity while mark the disadvantageous constitutional parameters in drawing medication: A different substitution does ensure additional efficiency in bioactivity.

Keywords

Main Subjects

Chemistry

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Journal of University of Anbar for Pure Science

Preparation, Antimicrobial Evaluation and Molecular docking of New 2,3-Substituted [1,3] Benzooxazin-4-one derivatives

References

References

Volume 14, Issue 2
August 2020
Page 38-46

Preparation, Antimicrobial Evaluation and Molecular docking of New 2,3-Substituted [1,3] Benzooxazin-4-one derivatives

References

References

Volume 14, Issue 2August 2020Page 38-46

Volume 14, Issue 2
August 2020
Page 38-46