SYNTHESIS, AND BIOLOGICAL EVALUATION OF NEWLY SUNTHESIZED TRIAZOLOTRIAZINES AND TRIAZOLOTRAIZINES DERIVATIVES

M. Mohammed, Hameed

doi:10.37652/juaps.2017.141586

Document Type : Research Paper

Author

Hameed M. Mohammed

University of Fallujah - College of Medicine

https://doi.org/10.37652/juaps.2017.141586

Abstract

Novel 8-(4-fluorophenyl)-6,6-diphenyl-3-(pyrimidin-4-yl) -5,6,7,8-tetrahydro-6l5-[1,2,4]triazolo [4,3-a][1,3,5]diazaphosphinin-6-ol(5),8-(4-fluorophenyl)-6-phenyl-3-(pyrimidin-4-yl)-7,8-dihydro [1,2,4]triazolo [4,3-b][1,2,4]triazine (6), 8-(4-fluorophenyl)-6-methyl-3-(pyrimidin-4-yl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-7(8H)-one (7) and 8-(4-fluorophenyl)-3-(pyrimidin-4-yl)-[1,2,4]triazolo[4,3-b][1,2,4]triazine-6,7(5H,8H)-dione (8) and 7-(pyrimidin-4-yl)-3,4-dihydro-[1,2,4]triazolo[4,e][1,2,4,5,3]tetrazaphosphinine (10), 3-(pyrimidin-4-yl)-1,7-dihydro-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine (11), 6-(2-chloro-6-fluorophenyl)-3-(pyrimidin-4-yl)-1,5,6,7,8,8a-hexahydro-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine (12), 3-(pyrimidin-4-yl)-1,7,8,8a-tetrahydro-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine-6(5H)-thione (13) and 3-(pyrimidin-4-yl)-1,7,8,8a-tetrahydro-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazin-6(5H)-one (14) have been synthesized via heterocyclization of 3-(pyridin-4yl)-4-amino-5-substituted amino-1,2,4-triazole (3) and 3-(pyridin-4yl)-4-amino-5-hydrazino-1,2,4-triazole (9) with α,β-bifunctional reagents such as chloromethyldiphenyl-phosphanoxide, phenacyl bromide, pyruvic acid, diethyl oxalate, triethylphosphite, triethyl orthoformate, fluorinated benzaldehydes, ethyl chloroformate and carbon disulfide in different experimental conditions. The molecular structures of the synthesized target molecules were elucidated by FT-IR, 1H NMR, 13C NMR and mass spectral data, in addition to the fine elements analysis C.H.N.% data. The antimicrobial and anti-inflammatory effects of the obtained derivatives were evaluated and compared with that of the standard Indomethacin, Nalidixic acid and Nystatin.

Keywords

Main Subjects

Chemistry

References

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Journal of University of Anbar for Pure Science

SYNTHESIS, AND BIOLOGICAL EVALUATION OF NEWLY SUNTHESIZED TRIAZOLOTRIAZINES AND TRIAZOLOTRAIZINES DERIVATIVES

References

References

Volume 11, Issue 2
August 2017
Page 25-33

SYNTHESIS, AND BIOLOGICAL EVALUATION OF NEWLY SUNTHESIZED TRIAZOLOTRIAZINES AND TRIAZOLOTRAIZINES DERIVATIVES

References

References

Volume 11, Issue 2August 2017Page 25-33

Volume 11, Issue 2
August 2017
Page 25-33