Author

General Directorate of Education in Anbar, Gifted Guardianship Committee, Ministry of Education in Iraq, Anbar, Iraq

Abstract

In response to a meal, the signals of satiety suppress the signals of hunger (meaning to finish the meal). These signals originate in the pancreas and gastrointestinal tract, transmitting information from the periphery to the brain (by the vagus nerve or the circulation). The study aimed to estimate whether the serum level of Cholecystokinin (CCK) in three male groups is influenced by their type of food. The current study included Sixty volunteers of adult males (normal-weight group n=20, overweight group n=20, and obese I group n=20) (21- 24 years). The blood samples were taken from subjects in the afternoon after (30 minutes–2 hours) from lunch was consumed, during March 2021 till June 2021. ELIZA kit was used to assay the serum concentration of the Cholecystokinin hormone. The anthropometric measurements were done, such as body weight and height, to calculate body mass index (BMI) by special formula, and the subjects were assorted depending on WHO body mass index (BMI) classification. Cholecystokinin showed a significant decrease (p<0.05) in obese I (311.201±21.542) and overweight (353.494 ± 43.915) as compared with the normal weight group (646.002 ± 46.344). A significant negative correlation was noticed between the hormone and body weight. Eating palatable food leads to uncontrolled ingesting behaviors due to the shift from homeostatic to hedonic regulatory mechanisms of food intake. These changes occur primarily in individuals with obesity and thus lead to an irregularity in the secretion of anorexigenic hormones.
 

 

Keywords

Main Subjects

[1]    L. D. Ruiz, M. L. Zuelch, S. M. Dimitratos, and R. E. Scherr. (2020) “Adolescent obesity: Diet quality, psychosocial health, and cardiometabolic risk factors,” Nutrients.
[2]    Ş. Akkartal and C. Gezer, “Is Nutrition Knowledge Related to Diet Quality and Obesity. (2020)” Ecol. Food Nutr..
[3]    S. Mörkl, M. I. Butler, A. Holl, J. F. Cryan, and T. G. Dinan. (2020) “Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry,” Current Nutrition Reports.
[4]    E. M. Flores, A. T. Nguyen, M. A. Odem, G. T. Eisenhoffer, and A. M. Krachler. (2020) “The zebrafish as a model for gastrointestinal tract–microbe interactions,” Cellular Microbiology.
[5]    Y. Yu, W. Yang, Y. Li, and Y. Cong. (2020) “Enteroendocrine Cells: Sensing Gut Microbiota and Regulating Inflammatory Bowel Diseases,” Inflamm. Bowel Dis.
[6]    T. M. Le et al. (2020) “The interrelationship of body mass index with gray matter volume and resting-state functional connectivity of the hypothalamus,” Int. J. Obes.
[7]    E. S. Bliss and E. Whiteside, “The gut-brain axis, the human gut microbiota and their integration in the development of obesity. (2018)” Frontiers in Physiology.
[8]    S. Yousefvand and F. Hamidi. (2020) “Role of Paraventricular Nucleus in Regulation of Feeding Behaviour and the Design of Intranuclear Neuronal Pathway Communications,” International Journal of Peptide Research and Therapeutics.
[9]    J. R. Dalenberg et al. (2020) “Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans,” Cell Metab.
[10]  A. N. Gearhardt and J. Hebebrand. (2021) “The concept of ‘food addiction’ helps inform the understanding of overeating and obesity: Debate Consensus,” American Journal of Clinical Nutrition.
[11]  J. A. Williams. (2019) “Cholecystokinin (CCK) regulation of pancreatic acinar cells: Physiological actions and signal transduction mechanisms,” Compr. Physiol.
[12]  P. D. Whissell et al. (2019) “Selective activation of cholecystokinin-expressing GABA (CCK-GABA) neurons enhances memory and cognition,” eNeuro.
[13]  Q. Yang et al. (2018) “‘Living High-Training Low’ improved weight loss and glucagon-like peptide-1 level in a 4-week weight loss program in adolescents with obesity,” Med. (United States).
[14]  E. Tsuda et al. (2021) “Content knowledge acquisition in physical education: Evidence from knowing and performing by majors and Nonmajors,” J. Teach. Phys. Educ.
[15]  A. Astrup. (2018) “Personalized dietary management of obesity based on simple biomarkers,” Obes. Facts.
[16]  M. P. Lasschuijt, K. de Graaf, and M. Mars. (2021)“Effects of oro-sensory exposure on satiation and underlying neurophysiological mechanisms—what do we know so far,” Nutrients.
[17]  E. T. Rolls(2020) “The texture and taste of food in the brain,” Journal of Texture Studies.
[18]  T. Banerjee, V. Chattaraman, H. Zou, and G. Deshpande (2020)“A neurobehavioral study on the efficacy of price interventions in promoting healthy food choices among low socioeconomic families,” Sci. Rep.
[19]  N. V. Di Patrizio. (2021) “Endocannabinoids and the gut-brain control of food intake and obesity,” Nutrients.
[20]  L. M. Mongioì et al. (2020) “Effectiveness of a very low calorie ketogenic diet on testicular function in overweight/obese men,” Nutrients.
[21]  E. Carbonneau et al.(2021) “Liking for foods high in salt and fat is associated with a lower diet quality but liking for foods high in sugar is not – Results from the PREDISE study,” Food Qual. Prefer.
[22]  W. L. Yap, C. M. Ng, and S. Kaur (2019) “Poor Diet Quality among Overweight/Obese (OW/OB) young adults in klang valley, Malaysia: A case-control study,” Pertanika J. Soc. Sci. Humanit.
[23]  L. S. Chow et al. (2020) “Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study,” Obesity.
[24]  J. Ueda, C. Spence, and K. Okajima. (2020) “Effects of varying the standard deviation of the luminance on the appearance of food, flavour expectations, and taste/flavour perception,” Sci. Rep.
[25]  A. Mohammadbeigi et al. (2018)“Fast food consumption and overweight/obesity prevalence in students and its association with general and abdominal obesity,” J. Prev. Med. Hyg.
[26]  H. Ao, J. Li, O. Li, M. Su, and X. Gao (2020) “Fructose vs glucose decreased liking/wanting and subsequent intake of high-energy foods in young women,” Nutr. Res.
[27]  D. Handayani et al. (2020) “Plasma Glucagon-Like Peptide-1 and Cholecystokinin Responses to Fast Food in Healthy-Weight and Obese Men,” J. Kedokt. Brawijaya.